货号 |
纯度 |
规格 |
货期 |
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C24404-5g |
≥98.0% |
5g |
一周 |
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C24404-25g |
≥98.0% |
25g |
一周 |
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CAS |
65277-42-1 |
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名称 |
酮康唑 |
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英文名称 |
Ketoconazole |
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分子式 |
C26H28Cl2N4O4 |
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分子量 |
531.43 |
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敏感性 |
对热敏感 |
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溶解性 |
SolubleinDMSO(20mg/mLwarm),ethanol(20mg/mLwarm),chloroform,water(<1mg/mL),andmethanol |
存贮条件 |
储存温度2-8℃ |
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溶解性 |
SolubleinDMSO(20mg/mLwarm),ethanol(20mg/mLwarm),chloroform,water(<1mg/mL),andmethanol |
产品介绍 |
Ketoconazoleisanimidazole-containingsmallmoleculeinhibitorofcytochromeP-450-dependentstepsinthebiosynthesisofsteroidhormones;alsoinhibitsTXASynthase(thromboxanesynthetase)and5-LO(5-lipoxygenase)activity.Ketoconazoleexhibitsantimetastatic,antineoplastic,andantipsoriaticactivity.Inhibitionof5-LO(5-lipoxygenase)byKetoconazoleinterruptsarachidonicacid-derivedleukotrieneproduction,whichwascorrelatedtoasuppressionofleukotriene-mediatedanaphylacticbronchoconstrictioninguineapigs.KetoconazoleisdescribedasreducingplateletcellularlevelsofthromboxaneA2,suppressingthromboxaneA2-mediatedincreaseofmicrovascularpermeabilityinresponsetoischemiainsults.Ketoconazoleproducesanantiandrogeneffectthroughinhibitionofadrenocorticoidbiosynthesis,suppressingtheadrenalsecretionofandrogensandattenuatingcortisolresponse.KetoconazoleisaninhibitorofCYP17A1,CYP3A4andCYP3A5 |
别名 |
Nizoral,Extina,Xolegel,Kuric;1-(4-(4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone;Nizoral,Extina,Xolegel,Kuric;1-(4-(4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone |
应用 |
AninhibitorofCYPproteins,thromboxanesynthetase,and5-LO |
信号词 |
Danger |
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警示性声明 |
P201-P273-P301+P310-P308+P313-P501 |
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个人防护设备 |
Eyeshields,Faceshields,Gloves,typeP2(EN143)respiratorcartridges |
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