产品介绍 |
Indirubin,alsoknownasisoindigotin,isaninhibitorofcyclin-dependentkinases(CDK1/cyclinB(IC50=10μM),CDK2/cyclinA(IC50=2.2μM),CDK2/cyclinE(IC50=7.5μM),CDK4/cyclinD1(IC50=12μM),CDK5/p35(IC50=5.5μM))andofGSK-3β(IC50=600nM).Studiesinvestigatingfunctionalisoindigosshowthattheyhavetheabilitytodisruptcellgrowthandproliferation.Thecompoundisapotentarylhydrocarbonreceptorligandandisfoundinhumanurineandfetalbovineserum.Synthesizedisoindigo-basedoligothiophenesareusedtostudyheterojunctionsolarcells.ShowntoinhibitallergiccontactdermatitisbyregulatingThelpermediatedimmunesysteminaDNCB-inducedmodel. |